I put movement keys on SDF (left strafe, fwd, right strafe) and then use QWERTYAGZXCVB. I’m using a 12-button mouse, but I don’t like it. It’s the Corsair Scimitar and I can easily reach buttons 4 – 12, but the first rank and button 1 in particular is very difficult. Button 1 is so close to the desk that I can’t effectively engage it.
Anyway, rotational spells are on WERT, Purify on Q, Healing Stream Totem on A, Shear on G, focus Shear is on SHIFT-G, Cap on Z, Healing Tide on X. Major cooldowns are on ALT-Q through ALT-R. I haven’t set it up yet, but I plan to use 1 – 3 for Arena 1 – 3 Wind Shear and ALT-1 through ALT-3 for Arena 1-3 Hex. MW-up is Party-1, MW-dn is Party-2.
I use SHIFT for self-cast.
On my mouse, buttons 4 – 6 are Flame Shock, Lava Burst, and Lightning Bolt. Button 3 is Bloodlust, Button 2 is Chain Lightning. Button 7 is Ghost Wolf, 8 is Healing Rain, 11 is Chain Heal. ALT-7 is my ground mount, and ALT-8 is flying mount.